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Generic Name: progesterone
Brands: Prometrium

What is the most important information I should know about Prometrium?

· Use caution when driving, operating machinery, or performing other hazardous activities. Prometrium may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

· Do not take Prometrium brand of Prometrium if you are allergic or sensitive to peanuts. Prometrium capsules contain peanut oil and should never be used by people allergic to peanuts.


What is Prometrium?

· Prometrium is a female hormone important for the regulation of ovulation and menstruation.

· Prometrium is used to prevent overgrowth of the endometrium of postmenopausal women who have not had a hysterectomy and are receiving estrogen replacement therapy. Prometrium is also used to treat the absence of menstruation due to Prometrium deficiency.

· Prometrium may also be used for purposes other than those listed in this medication guide.


What should I discuss with my healthcare provider before taking Prometrium?

· Do not take Prometrium without first talking to your doctor if you have      ·an allergy to peanuts (the Prometrium brand of Prometrium contains peanut oil);     ·a bleeding or blood-clotting disorder,     ·breast cancer,     ·cancer of a genital organ,     ·liver disease, or     ·undiagnosed vaginal bleeding.

· Before taking this medication, tell your doctor if you have     ·epilepsy or a seizure disorder,     ·migraines,     ·asthma,     ·kidney disease,     ·heart disease,     ·diabetes, or     ·a history of depression.

· You may not be able to take Prometrium, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

· Prometrium is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take Prometrium without first talking to your doctor if you are pregnant.

· Prometrium passes into breast milk. It is not known whether Prometrium will harm an unborn baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.


How should I take Prometrium?

· Take Prometrium exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.


· Take each dose with a full glass of water.

· Prometrium is usually taken in the evening. Prometrium may be taken with food if it upsets your stomach. Your doctor may prescribe doses to be taken only on a certain number of days of your menstrual cycle. Follow your doctor's instructions.

· Store Prometrium at room temperature away from moisture and heat.


What happens if I miss a dose?

· Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the dose you missed and take only your next dose as directed. Do not take a double dose of this medication.


What happens if I overdose?

· Seek emergency medical attention.

· Symptoms of a Prometrium overdose are not known.


What should I avoid while taking Prometrium?

· Use caution when driving, operating machinery, or performing other hazardous activities. Prometrium may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.


What are the possible side effects of Prometrium?

· Stop taking Prometrium and seek emergency medical attention or call your doctor immediately if you experience any of the following serious side effects:     ·an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);     ·shortness of breath or pain in your chest;     ·a sudden severe headache;     ·visual changes;     ·a painful, red, swollen leg;     ·numbness or tingling in an arm or leg;     ·prolonged, heavy, vaginal bleeding;     ·stomach or side pain; or     ·yellowing of your skin or eyes.

· Other, less serious side effects may be more likely to occur. Continue to take Prometrium and talk to your doctor if you experience     ·dizziness;     ·drowsiness;     ·headache;     ·breast pain or tenderness;     ·abdominal pain or distention;     ·diarrhea;     ·vaginal discharge; or     ·mood changes, anxiety, irritability, or depression.

· Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.


What other drugs will affect Prometrium?

· Prometrium has not been reported to interact significantly with any other medicines. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines during treatment with Prometrium.


Where can I get more information?

· Your pharmacist has additional information about Prometrium written for health professionals that you may read.

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